Multi Epitopes Vaccine Prediction against Severe Acute Respiratory Syndrome (SARS) Coronavirus Using Immunoinformatics Approaches

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Coronavirus in severe acute respiratory syndrome (SARS).

In November 2002, an outbreak of a life-threatening ‘atypical pneumonia’ for which no etiological agent could be identified occurred in Guangdong Province, China. In March 2003, a similar outbreak was reported in Hong Kong [1]. Cases of similar respiratory illness were subsequently reported globally including China, Taiwan, Singapore, Vietnam, Canada and USA. This syndrome is a new clinical ent...

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Severe acute respiratory syndrome (SARS).

S evere acute respiratory syndrome (SARS) originated in the Guangdong province in southern China and spread by way of Hong Kong to the rest of the world in the spring of 2003. According to the most widely accepted theory at the time of this writing (July 2003), the likely culprit is a novel coronavirus that ‘‘jumped’’ from animals to humans. Thousands around the world have been infected and hun...

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[Severe acute respiratory syndrome (SARS)].

Several cases of life threatening respiratory disease with no identifiable cause were reported from Guangdong Province, China; these were soon followed by reports from many other countries. The disease was named as severe acute respiratory syndrome (SARS). A novel coronavirus, isolated from the respiratory secretions of patients, has been implicated in the causation of SARS. The modes of transm...

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[Severe acute respiratory syndrome (SARS)].

March 12, 2003, the WHO issued a Global Alert on the atypical pneumonia of unknown cause that broke out in Asia, naming the disease SARS. Supported by the cooperation of specialists from various countries, the WHO announced on April 15 that the pathogen was a new-type of coronavirus and proposed calling it SARS Coronavirus. Following international efforts, the WHO declared on July 5 that there ...

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Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.

BACKGROUND The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response...

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ژورنال

عنوان ژورنال: American Journal of Microbiological Research

سال: 2018

ISSN: 2328-4129

DOI: 10.12691/ajmr-6-3-5